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Chronic stress associated with spousal caregiving of patients with Alzheimer's dementia is associated with downregulation of B-lymphocyte GH mRNA.

Identifieur interne : 002E99 ( Main/Exploration ); précédent : 002E98; suivant : 002F00

Chronic stress associated with spousal caregiving of patients with Alzheimer's dementia is associated with downregulation of B-lymphocyte GH mRNA.

Auteurs : H. Wu [États-Unis] ; J. Wang ; J T Cacioppo ; R. Glaser ; J K Kiecolt-Glaser ; W B Malarkey

Source :

RBID : pubmed:10219013

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English descriptors

Abstract

It has been demonstrated that growth hormone (GH) is synthesized and secreted by human peripheral mononuclear cells (PBMC), and the expression of GH mRNA can be found throughout the human immune system.

DOI: 10.1093/gerona/54.4.m212
PubMed: 10219013


Affiliations:


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Le document en format XML

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<title xml:lang="en">Chronic stress associated with spousal caregiving of patients with Alzheimer's dementia is associated with downregulation of B-lymphocyte GH mRNA.</title>
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<name sortKey="Wu, H" sort="Wu, H" uniqKey="Wu H" first="H" last="Wu">H. Wu</name>
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<nlm:affiliation>Department of Medicine, The Ohio State University, USA.</nlm:affiliation>
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<name sortKey="Wang, J" sort="Wang, J" uniqKey="Wang J" first="J" last="Wang">J. Wang</name>
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<name sortKey="Glaser, R" sort="Glaser, R" uniqKey="Glaser R" first="R" last="Glaser">R. Glaser</name>
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<name sortKey="Kiecolt Glaser, J K" sort="Kiecolt Glaser, J K" uniqKey="Kiecolt Glaser J" first="J K" last="Kiecolt-Glaser">J K Kiecolt-Glaser</name>
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<term>Aged</term>
<term>Alzheimer Disease</term>
<term>B-Lymphocytes (immunology)</term>
<term>B-Lymphocytes (metabolism)</term>
<term>Caregivers</term>
<term>Case-Control Studies</term>
<term>Chronic Disease</term>
<term>Down-Regulation (physiology)</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Human Growth Hormone (genetics)</term>
<term>Human Growth Hormone (metabolism)</term>
<term>Humans</term>
<term>In Situ Hybridization</term>
<term>Leukocytes, Mononuclear (metabolism)</term>
<term>Middle Aged</term>
<term>Polymerase Chain Reaction</term>
<term>RNA, Messenger (genetics)</term>
<term>RNA, Messenger (metabolism)</term>
<term>Spouses</term>
<term>Stress, Physiological (immunology)</term>
<term>Stress, Physiological (metabolism)</term>
<term>Stress, Physiological (physiopathology)</term>
<term>Stress, Psychological (immunology)</term>
<term>Stress, Psychological (metabolism)</term>
<term>Stress, Psychological (physiopathology)</term>
<term>T-Lymphocytes (metabolism)</term>
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<term>ARN messager (génétique)</term>
<term>ARN messager (métabolisme)</term>
<term>Adulte d'âge moyen</term>
<term>Agranulocytes (métabolisme)</term>
<term>Aidants</term>
<term>Conjoints</term>
<term>Femelle</term>
<term>Hormone de croissance humaine (génétique)</term>
<term>Hormone de croissance humaine (métabolisme)</term>
<term>Humains</term>
<term>Hybridation in situ</term>
<term>Lymphocytes B (immunologie)</term>
<term>Lymphocytes B (métabolisme)</term>
<term>Lymphocytes T (métabolisme)</term>
<term>Maladie chronique</term>
<term>Maladie d'Alzheimer</term>
<term>Réaction de polymérisation en chaîne</term>
<term>Régulation de l'expression des gènes</term>
<term>Régulation négative (physiologie)</term>
<term>Stress physiologique (immunologie)</term>
<term>Stress physiologique (métabolisme)</term>
<term>Stress physiologique (physiopathologie)</term>
<term>Stress psychologique (immunologie)</term>
<term>Stress psychologique (métabolisme)</term>
<term>Stress psychologique (physiopathologie)</term>
<term>Sujet âgé</term>
<term>Études cas-témoins</term>
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<term>Human Growth Hormone</term>
<term>RNA, Messenger</term>
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<term>ARN messager</term>
<term>Hormone de croissance humaine</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr">
<term>Lymphocytes B</term>
<term>Stress physiologique</term>
<term>Stress psychologique</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en">
<term>B-Lymphocytes</term>
<term>Stress, Physiological</term>
<term>Stress, Psychological</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en">
<term>B-Lymphocytes</term>
<term>Human Growth Hormone</term>
<term>Leukocytes, Mononuclear</term>
<term>RNA, Messenger</term>
<term>Stress, Physiological</term>
<term>Stress, Psychological</term>
<term>T-Lymphocytes</term>
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<term>ARN messager</term>
<term>Agranulocytes</term>
<term>Hormone de croissance humaine</term>
<term>Lymphocytes B</term>
<term>Lymphocytes T</term>
<term>Stress physiologique</term>
<term>Stress psychologique</term>
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<term>Régulation négative</term>
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<term>Down-Regulation</term>
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<term>Stress physiologique</term>
<term>Stress psychologique</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Stress, Physiological</term>
<term>Stress, Psychological</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Aged</term>
<term>Alzheimer Disease</term>
<term>Caregivers</term>
<term>Case-Control Studies</term>
<term>Chronic Disease</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>In Situ Hybridization</term>
<term>Middle Aged</term>
<term>Polymerase Chain Reaction</term>
<term>Spouses</term>
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<keywords scheme="MESH" xml:lang="fr">
<term>Adulte d'âge moyen</term>
<term>Aidants</term>
<term>Conjoints</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hybridation in situ</term>
<term>Maladie chronique</term>
<term>Maladie d'Alzheimer</term>
<term>Réaction de polymérisation en chaîne</term>
<term>Régulation de l'expression des gènes</term>
<term>Sujet âgé</term>
<term>Études cas-témoins</term>
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<front>
<div type="abstract" xml:lang="en">It has been demonstrated that growth hormone (GH) is synthesized and secreted by human peripheral mononuclear cells (PBMC), and the expression of GH mRNA can be found throughout the human immune system.</div>
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